Primary Prophylaxis of Gastric Variceal Bleeding Comparing Cyanoacrylate Injection and Beta-Blockers in Patients with Liver Cirrhosis: A Randomized Controlled Trial

Abstract

Background and study aim: The bleeding from gastric varices are more severe, requiring more blood transfusions, and has a higher mortality rate than esophageal variceal bleeding, there is little data on primary prophylaxis of GV bleeding, we compared the efficacy of cyanoacrylate injection and beta-blockers in primary prophylaxis of gastric variceal bleeding.

Methods:Cirrhotics with gastroesophageal varices type 2 with eradicated esophageal varices or large isolated gastric varix type 1, who had never bled from gastric varix, were randomized to cyanoacrylate injection (Group I, n = 30), beta-blockers (Group II, n = 30) or no treatment (Group III, n = 30). Primary endpoints were bleeding from gastric varix or death.

Results:bleeding from gastric varices over 6 months follow up was 6.67% in Group I, 20% in Group II, 36.67% in Group III (p = 0.017). GV obliterated or decreased in size 42.86% and 57.14% of group I respectively. No patients neither in group II nor in group III had an obliteration or decrease in GV size. (p < 0.001).

Conclusion:Primary prophylaxis in patients with gastric varices is recommended to reduce the risk of first bleeding. Cyanoacrylate injection is more effective than beta-blocker therapy in preventing first gastric variceal bleeding.

Read More About This Article: https://juniperpublishers.com/argh/ARGH.MS.ID.555922.php

Read More Juniper Publishers Google Scholar Articles: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=4DviEq0AAAAJ&citation_for_view=4DviEq0AAAAJ:dfsIfKJdRG4C


 

Comments

Post a Comment

Popular posts from this blog

A Modified Sequential Regimen of Helicobacterpylori Treatment Enforced by Bacillus clausii and Zinc Carnosine Complex Yields High Eradication Rates_Juniper Publishers

Image
  ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY JUNIPER PUBLISHERS   Authored by Dajani AI      Abstract Introduction: Over the past decade a worldwide trend of decline in the cure rates of Helicobacter pylori is observed. Current eradication rates achieved by the standard triple therapy are below 70%. Sequential therapy had provided a potential alternative that would compensate for the unmet performance of triple therapy. Despite its superiority to triple therapy, the excellent results reported initially were not reproduced by other investigators work. Adding adjuvant agents was also found to improve further the success rate of eradication. Probiotics emerged as a useful adjunct in treatment and prophylaxis of Helicobacter pylori infection. The nutritional supplement Zinc carnosine complex is another adjuvant which is believed to add value to the treatment. Patients and method: an open label randomized observational clinical study ...
Read more

Association between Nonalcoholic Fatty Liver Disease and Carotid Atherosclerosis-Juniper Publishers

Image
JUNIPER PUBLISHERS-ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY Abstract Aim/Background: Nonalcoholic fatty liver disease (NAFLD) frequently accompanies to the criteria of Metabolic Syndrome (MetS) like obesity, diabetes, and dyslipidemia. It is recently approved as a liver attaint of MetS. While MetS is a highly atherogenic condition we examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries. Methods: Carotid intima-media thickness and cardiovascular risk factors were evaluated in 64 patients with an ultrasound diagnosis of primary NAFLD and 64 matched population controls. Metabolic syndrome was established according to WHO and ATP-III criteria. IMT values were evaluated according to protocols of standard measurements of carotid artery. Results: The metabolic syndrome and all its individual features were significantly (P<0.001) more frequent in NAFLD patients than in control subjects. P...
Read more

Discussion on Liver Preoperative Planning System Based on Deep Learning_Juniper Publishers

Image
      ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY JUNIPER PUBLISHERS     Authored by Nishant Shukla    Abstract Liver cancer has become the second largest cancer death rate in the world, and the prevention and treatment of liver diseases is extremely urgent. It has grown up to be a hot spot and focus of the world. With the development of medical imaging and the introduction of “precise surgery”, the development of preoperative planning system for liver diseases has become a research hotspot. Accurate preoperative planning system relies on the development of image processing technology, and the introduction and application of deep learning just improve the accuracy of image processing technology and promote the development process of liver preoperative planning system. This paper mainly expounds the main problems of today’s deep learning-based liver preoperative planning system and discusses the solution to the problem and th...
Read more