Hepatocellular Carcinoma: Epidemiologic, Clinical Features And Treatment In Senegal

Abstract
Background: Liver cancer is the third leading cause of cancer deaths worldwide. Hepatocellular carcinoma (HCC) is the most common
primary liver tumour. The aim of our study was to evaluate the epidemiological, diagnostic, therapeutic and outcome aspects of HCC.
Materials and methods: We conducted a bicentric, retrospective, descriptive and analytical study over 19 months from January 1, 2018
to July 31, 2019 in the department of gastroenterology and hepatology of hospital Aristide le Dantec (Dakar, Senegal) and at the Marie Louise
BREVIE clinic at the hospital Principal of Dakar (Dakar, Senegal). We included all patients with a diagnosis of HCC.
Results: We include 104 patients, 89 were men (85.6%). The mean age was 46.7 years [18-78 years]. The most frequent clinical signs
were abdominal pain (95.2%). AFP levels were elevated in 77.88 % of cases. The CT scan revealed a wash-in-wash-out appearance in 100 cases
(96.1%). Histology revealed HCC in 5 cases (4.8%). HCC developed in a cirrhotic liver in 99 cases (95.1%). This cirrhosis was viral B in 69 cases
(69.7 %). Patients were BCLC C in 70.2 %. One patient underwent a left hepatectomy. Chemoembolisation was performed in three patients.
Eighty-three patients (79.8%) were lost to follow-up and 21 (20.2%) died. The mean survival of deceased patients was 5 months [ 2-13 months].
Conclusion: In our country HCC, frequently affects young adult males with viral B cirrhosis. Its prognosis is poor because most patients are
diagnosed at advanced stage of the disease.

 

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