HER-2 Overexpression in Gastric and Gastroaesophageal Cancer: A Different Disease among Gastric Adenocarcinoma Subtypes
ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY JUNIPER PUBLISHERS Authored by C Caglevic Introduction Gastric adenocarcinoma is currently one of the most frequent malignancies worldwide, becoming the fifth place in incidence and third place in mortality among solid tumors [1]. The geographical distribution of this disease is variable, being most common in countries with worse water quality and deficient food storage [2]. In the Pacific coast of South America, mainly in countries like Chile and Peru, probably due to a high prevalence of pathogenic Helicobacter Pylori subtypes, gastric cancer is a serious public health problem that involves a higher mortality when compared with developed countries of North America and Europe [3]. In high income countries, gastric cancer incidence has decreased during the last decades due to an important impact in environment that overlaps the genetic predisposition for this malignancy [4,5]. Despite its hig...