Serum Serotonin As A Novel Marker For Hepatocellular Carcinoma-Advanced Research in Gastroenterology & Hepatology-Juniper Publishers

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SERUM SEROTONIN AS A NOVEL MARKER FOR HEPATOCELLULAR CARCINOMA

Authored by Elsayed Ibrahim Elshayeb

Aim of the Work: To investigate the role of serum serotonin as a novel marker for diagnosis of Hepatocellular carcinoma In comparison with serum alpha fetoprotein.
Introduction: Hepatocellular carcinoma is the most common liver cancer and is a disease with poor prognosis. In addition to its function as a neurotransmitter and vascular active molecule, Serotonin is also a mitogen for hepatocytes and promotes liver regeneration and may be involved in tumorigenesis of HCC.
Methods: The study conducted on 136 patients and 20 healthy subjects as control group. Patients classified into two groups, 68 Cirrhotic with HCC as group I and 68 only cirrhotic without HCC as group II. Patients and controls underwent through history taking, full clinical examination with Child pugh score laboratory. Investigations including Complete blood count, Liver function tests, Creatinine, serum AFP and Serotonin levels in addition to abdominal ultrasound and Triphasic CT abdomen.
Results: Cirrhotic Patients presented with HCC showed significantly higher levels of serotonin, alpha fetoprotein, albumin and white blood cell count compared to pure cirrhotic group without HCC, however, HCC patients showed lower levels of AST, ALT, bilirubin and platelet count compared to cirrhotic patients. HCC patients were more in elder, associated with male gender and showed shorter prothrombin. A significant positive correlation between serum AFP and serotonin. r=0.594, P<0.001 AFP at 0.5 ng /ml is a cutoff with sensitivity 100%, specificity 70%, PPV 91.9% and Accuracy 97.6% respectively for diagnosis of HCC while Sr. Serotonin >510ng/ml is a cutoff with 89.71% sensitivity, 85% specificity, 95.3 % PPV, 70.8 % NPV and 96.6 % accuracy respectively for diagnosis of HCC.
Conclusion: Serotonin could be a novel maker for diagnosis of HCC and may be used together with serum AFP for screening of HCC in cirrhotic patients.

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