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Hebatitis B Virus Genotypes in Pakistan_Juniper Publishers

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      ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY JUNIPER PUBLISHERS    Authored by Majid Mahmood  Mini Review Hepatitis B virus (HBV) infection is one of the most common causes of human death worldwide [ 1 - 3 ]. HBV has ten genotypes alphabetized as A to J which are not uniformly distributed in different parts of the world. The genotypes are important in treatment of the infection as they influence the disease progression, baseline viral load and the patients' response to treatment. Distribution of HBV genotypes in the world According to Bonino et al. [ 2 ], who reviewed the global distribution of HBV genotypes, various HBV genotypes are not uniformly distributed all over the world. Further, their distribution is influenced by ethnic and geographical factors. Genotype A is common in Brazil, North America, Northwest Europe, South Asia, Central Africa, Tunisia and Benin [ 2 , 4 , 5 ]. Genotype B is common in China, Hong Kong, I...

Defensive Effect of 30kDa Protein from Silkworm, Bombyxmori against Apoptosis Induced Diseases_Juniper Publishers

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  ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY JUNIPER PUBLISHERS   Authored by Muthukalingan Krishnan   Abstract During embryonic development of the domesticated silkworm, Bombyx mori, 30kDa proteins comprise about 35% of the total embryo yolk proteins and function as storage proteins. In the early and midpupal developmental phase 30kDa proteins is one among the most abundant components of hemolymph. Albeit, the 30kDa family proteins are important anti-apoptotic molecules in silkworm hemolymph, the underlying mechanism remains to be investigated. This article reviews 30kDa protein as a novel anti-apoptotic protein from silkworm, which also protects from Reactive Oxygen Species (ROS) generation. Keywords: 30kDa protein; Anti- apoptosis; ROS generation; Cardiovascular diseases Abbreviations: ROS: Reactive Oxygen Species; FB: Fat Body; MW: Molecular Weight Introducti...