ADVANCED RESEARCH IN GASTROENTEROLOGY & HEPATOLOGY JUNIPER PUBLISHERS Authored by Rima Khabbaz Opinion Dietary interventions have focused on reversing the disease induced catabolic state and identification of foods that exacerbate symptoms. The Hruska Postulate identifies Crohn's disease (CD) as the consequence of two inter-related actions involving Mycobacterium avium subspecies para tuberculosis (MAP). The potential for CD is created when a newborn, lacking effective acquired immunity, has to deal with infection by MAP. The consequence of ARGHesting MAP replication results in fixation of the pro-inflammatory cytokine response to MAP and the loss of immunological tolerance. The clinical manifestation of CD is contingent upon repeat MAP antigen challenges and the elicited cytokine responses that, in time, overwhelm the regenerative capacity of the lining gastrointestinal mucosa [ 1 , 2 ]. The genesis of dietary intervention in CD is no...
