Juniper Publishers Gastroenterology Open Access Journals

JUNIPER PUBLISHERS- Advanced Research in Gastroenterology & Hepatology NON-INVASIVE BIOMARKERS VS LIVER BIOPSY IN DIAGNOSING & STAGING NAFLD Authored by Parveen Malhotra Introduction: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease ranging from simple steatosis to inflammatory steatohepatitis (NASH) with increasing levels of fibrosis and ultimately cirrhosis. It has been considered the most common liver disease and the most frequent cause of elevated aminotransferases and cryptogenic cirrhosis. Aims and Objectives: To evaluate the role of non invasive biomarkers and compare them with liver biopsy in diagnosis and staging of Non Alcoholic Fatty Liver Disease Material and Methods: This study was conducted at Pt. B D Sharma, PGIMS, Rohtak. A total of forty consecutive patients of nonalcoholic fatty liver disease underwent liver biopsy, in addition to non-invasive biomarkers. P value of < 0.05 was taken as significant and <...

JUNIPER PUBLISHERS- Advanced Research in Gastroenterology & Hepatology SPECTRUM OF CELIAC DISEASE AT TERTIARY CARE CENTER OF NORTHEREN INDIA Authored by Parveen Malhotra Aim: This study conducted with aims to classify the endoscopic duodenal biopsies using modified Marsh grading in cases of suspected celiac disease and compare these grades with various clinical and serological parameters including serum TtG levels. Background: Celiac disease (CD), is a chronic immune-mediated disorder of small intestine that occurs in genetically predisposed populations. It is characterized by permanent intolerance to wheat gliadins and other cereal prolamins. The epidemiology of CD has iceberg characteristics¬ with more undiagnosed cases. The pathogenesis entails a T cell‐mediated immune response with production of auto antibodies directed against tissue transglutaminase or endomysium. The diagnosis of CD is currently based on both typical s...